Asian Journal of Research in Chemistry

Abstract

Two simple and sensitive visible spectrophotometric methods have been developed for the estimation of Tolperisone in pure and pharmaceutical dosage forms. Method A is based on co-ordinate complex formation between the drug and cobalt thiocynate (630 nm) and method B is based on charge transfer complex formation between drug and 2,3 dichloro- 5-6-dicyano 1-4,benzoquinone (DDQ 430 nm) .The absorbance are measured against the corresponding reagent blanks. The methods have been statistically evaluated and found to be precise and accurate.

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Abstract

Two simple and sensitive spectrophotometric methods have been developed for the estimation of Milnacipran in pure and pharmaceutical dosage forms. Method A is based on oxidative coupling of the drug with folin-ciocaltaeu reagent (F.C.reagent) λmax 780nm. Method B is based on oxidation followed by complex formation when the drug reacts with P-Methylamino phenolsulphate (Metol reagent) λmax 540nm. The absorbance of the colored species is measured against the corresponding reagent blank. These methods have been statistically evaluated and found to be precise and accurate.

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